Chunguang Guo

Understanding fibrosis in muscle regeneration

Our project aims to uncover how fibrosis develops in muscle at the cellular and molecular levels: which cells initiate it, how inflammatory and mechanical signals drive its progression, and why normal repair processes sometimes shift into harmful scarring. Understanding fibrosis in muscle is especially powerful, because the pathways that control scar formation are often shared across organs. By revealing the mechanisms that promote or restrain fibrosis in skeletal muscle, we hope to uncover principles that can guide new treatments for many fibrotic diseases—not just in muscle, but potentially in heart, lung, liver, and beyond.