Understanding the way cells communicate with each other to develop anti-ALS drugs

Amyotrophic lateral sclerosis (ALS) is a devastating disease in which the motor neurons that control movement gradually die, leading to muscle weakness, paralysis, and ultimately loss of vital functions like breathing. Although the brain and spinal cord are directly affected, muscles themselves play a critical role in keeping motor neurons healthy through a constant exchange of molecular signals. Our lab has been working on uncovering these communication pathways—how muscle cells support the nerves that innervate them, and how disruptions in this cross-talk can accelerate degeneration. Our project builds on this knowledge to develop new drugs that restore or strengthen these muscle-to-neuron support signals, offering a fresh therapeutic angle for ALS. By closing these gaps, we hope to create treatments that slow or even prevent the progression of ALS, ultimately preserving mobility, independence, and quality of life for patients.